Attachment and Growth of Fibroblast Cells on Poly (2-Methoxyethyl Acrylate) Analog Polymers as Coating Materials

The regulation of adhesion and the subsequent behavior fibroblast cells on surface biomaterials is important for successful tissue regeneration wound healing by implanted biomaterials. We have synthesized poly(ω-methoxyalkyl acrylate)s (PMCxAs; x indicates number methylene carbons between ester ethyl oxygen), with a carbon chain length = 2–6, to investigate cell including adhesion, proliferation, migration, differentiation collagen production. found that PMC2A suppressed spreading, protein adsorption, formation focal normal human dermal fibroblasts, while PMC4A surfaces enhanced them compared other PMCxAs. Our findings suggest activities attached PMCxA substrates can be modified changing in side chains polymers. These results indicate PMCxAs could useful coating materials use skin dressing applications.